期刊
INFLAMMATION
卷 40, 期 6, 页码 2129-2136出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-017-0653-y
关键词
inflammation; proliferation; migration; NFAT5; arterial smooth muscle cells
资金
- National Natural Science Foundation of China [81400294]
The increasing wall stress as is elicited by arterial hypertension promotes their reorganization in the vessel wall which may lead to arterial stiffening and contractile dysfunction. The nuclear factor of activated T cells 5 (NFAT5) pathway plays a role in regulating growth and differentiation in various cell types. We investigated whether the NFAT5 pathway was involved in the regulation of biomechanical stretch-induced human arterial smooth muscle cell (HUASMC) proliferation, inflammation, and migration. Herein, we showed that stretch promoted the expression of NFAT5 in human arterial smooth muscle cells and regulated through activation of c-Jun N-terminal kinase under these conditions. This may contribute to an improved activity of HUASMCs and thus promote reorganization in vascular remodeling processes such as hypertension-induced arterial stiffening and contractile dysfunction.
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