期刊
CURRENT BIOLOGY
卷 25, 期 20, 页码 R1002-R1018出版社
CELL PRESS
DOI: 10.1016/j.cub.2015.08.051
关键词
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资金
- European Research Council (ERC)
- DFG's Collaborative Research Centre (CRC) 1093
The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle progression during mitosis with the state of chromosome attachment to the mitotic spindle. The checkpoint prevents mitotic cells from exiting mitosis in the presence of unattached or improperly attached chromosomes, thus avoiding whole-chromosome gains or losses and their detrimental effects on cell physiology. Here, I review a considerable body of recent progress in the elucidation of the molecular mechanisms underlying checkpoint signaling, and identify a number of unresolved questions.
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