期刊
DATA IN BRIEF
卷 31, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.dib.2020.105866
关键词
Chondrocyte; Formyl peptide receptor; Articular cartilage; Osteoarthritis; Human
资金
- Swedish Research Council
- Stiftelsen Konung Gustaf V:s 80-arsfond
- IngaBritt och Arne Lundbergs Forskningsstiftelse
- Wilhelm and Martina Lundgrens Vetenskapsfond
- Adlerbertska Forskningsstiftelsen
- Rune och Ulla Amlovs stiftelse
- Stiftelsen Mary von Sydows donationsfond
- Kungl. Vetenskaps-och Vitterhets-Samhallet i Goteborg
The formyl peptide receptor 2 (FPR2) belongs to the family of seven-transmembrane G protein-coupled receptors (GPCR) and are expressed by many different cells but mainly studied in immune cells. FPR2 is involved in host defense against bacterial infections and clearance of damaged cells through the oxidative burst and chemotaxis of neutrophils. In addition, FPR2 has also been implicated as an immunomodulator in sterile inflammations, e.g. inflammatory joint diseases. Here we present data regarding FPR2 expression in human articular chondrocytes, isolated from healthy individuals and osteoarthritic patients, on both mRNA and protein level using qPCR and Imagestream flow cytometry. We also present data after receptor stimulation and monitoring of production of nitric oxide, reactive oxygen species, IL-6, IL-8 and MMP-3. The presented data show that human articular chondrocytes from patients with osteoarthritis as well as from healthy individuals express FPR2 both at mRNA and protein level. The biological relevance of FPR2 expression in chondrocytes needs to be further investigated. (c) 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license. ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
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