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Pivalic acid assisted Biginelli reaction for synthesis of dihydropyrimidinones and dihydrothiopyrimidinones

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NATL INST SCIENCE COMMUNICATION & INFORMATION RESOURCES-NISCAIR

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One-pot synthesis; green chemistry; heterocycles; bioactive compounds; pivalic acid; dihydropyrimidinones

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  1. Science & Engineering Research Board (SERB), Depathnent of Science and Technology (DST), Government of India
  2. Department of Science and Technology (DST), Government of Goa

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Herein is provided an alternate, simple, multigram scale, efficient route for Biginelli reaction for synthesis of dihydropyrimidinones using urea, ethylacetatoacetate, and benzaldehyde with pivalic acid.

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