期刊
CURRENT BIOLOGY
卷 25, 期 2, 页码 251-255出版社
CELL PRESS
DOI: 10.1016/j.cub.2014.11.061
关键词
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资金
- Swiss National Science Foundation [310030E_135910/1, 31003A_149753, CR33I13_143723, 31003A_153410]
- Claraz Foundation
- Geneva Neuroscience Center
- Swiss National Science Foundation (SNF) [31003A_149753, 310030E-135910, 31003A_153410] Funding Source: Swiss National Science Foundation (SNF)
Although sociability offers many advantages, a major drawback is the increased risk of exposure to contagious pathogens, like parasites, viruses, or bacteria [1]. Social species have evolved various behavioral strategies reducing the probability of pathogen exposure [2]. In rodents, sick conspecific avoidance can be induced by olfactory cues emitted by parasitized or infected conspecifics [3-6]. The neural circuits involved in this behavior remain largely unknown. We observed that olfactory cues present in bodily products of mice in an acute inflammatory state or infected with a viral pathogen are aversive to conspecifics. We found that these chemical signals trigger neural activity in the vomeronasal system, an olfactory subsystem controlling various innate behaviors [7]. Supporting the functional relevance of these observations, we show that preference toward healthy individuals is abolished in mice with impaired vomeronasal function. These findings reveal a novel function played by the vomeronasal system.
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