期刊
HETEROCYCLES
卷 100, 期 4, 页码 609-621出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-20-14236
关键词
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资金
- EPSRC [EP/J01821X/1]
- BEACON (ERDF)
- Welsh Government
Five analogues (7a-e) of the metabolite tiruchanduramine 1 were prepared. Compounds 7d and 7e were specific inhibitors of yeast alpha-glucosidase, whilst 7e specifically inhibited Bacillus alpha-glucosidase. Compounds 7b and 7c were the best inhibitors of beta-glucosidase. All 5 compounds inhibited beta-galactosidase, but once again 7e was the best inhibitor. It was apparent that different chain lengths in the compounds 7a-e affect the degree of inhibition. Some of the synthetic analogues show significantly improved inhibition of alpha-glucosidases when compared to tiruchanduramine 1 and also improved specificity.
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