期刊
HETEROCYCLES
卷 100, 期 2, 页码 177-193出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/REV-19-915
关键词
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资金
- Uehara Memorial Foundation
- Musashino Joshi-Gakuin
- JSPS KAKENHI [JP19K06975]
Pyranonaphthoquinone natural products are widely distributed in plants and microorganisms and have diverse biological activities. Angular benzochromenes are a small class of natural products isolated from Conospermum and Pentas plants. Of these, conocurvone was isolated from Conospermum as a trimeric pyranonaphthoquinone that has potent anti-HIV activity. We have focused on the total synthesis of compounds that exhibit biological activity or whose activity is enhanced upon oligomerization. This review describes the discovery and biological activities of the trimeric pyranonaphthoquinone conocurvone and related compounds, as well as our and other researchers' synthetic studies toward monomeric pyranonaphthoquinones.
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