期刊
WORLD JOURNAL OF MENS HEALTH
卷 38, 期 4, 页码 582-590出版社
KOREAN SOC SEXUAL MEDICINE & ANDROLOGY
DOI: 10.5534/wjmh.190160
关键词
Anastrozole; Clomiphene; Hypogonadism; Infertility; male; Testosterone
Purpose: Ta assess the conversion rate from clomiphene citrate (CC) monotherapy to combination CC+ anastrozole (AZ) therapy in hypogonadal men and the predictors associated with the initiation of AZ. Materials and Methods: A retrospective review of records from hypogonadal men treated with CC in a single fertility center was performed from 2013 to 2018. Patient age, body mass index (BMI), blood pressure, and reproductive hormones were obtained at baseline. Obesity was defined as BMI30 kg/m(2). Cox proportional hazards models were used to identify predictors of switching to combination CC+AZ therapy. Results: A total of 318 men on CC were included. Median (interquartile range) age was 34 years (30-39 years) and patients were followed for a median of 9 months (4-17 months). Of these, 97 (30.5%) were started on CC+AZ therapy. These patients had higher baseline BMI and estradiol, which in multivariable regression were significant predictors for switching to CC+AZ therapy. A threshold of 18.5 pg/mL for baseline estradiol provided the highest accuracy for predicting the addition of AZ after adjusting for baseline BMI and total testosterone levels. Conclusions: In our practice, following CC monotherapy, 30% of men were initiated on CC+AZ. Obesity (BMI00 kg/m(2)) and baseline estradiol 218.5 pg/mL can predict the conversion to combination therapy with addition of AZ. This information can be used to counsel patients and also help to identify patients who can be started on combination therapy upfront.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据