期刊
CHEMICAL COMMUNICATIONS
卷 56, 期 76, 页码 11235-11238出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc03201h
关键词
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资金
- National Science Foundation of China [21472151]
- Natural Science Foundation of Chongqing [cstc2019jcyj-msxmX0414]
- Fundamental Research Funds for the Central Universities [XDJK2019AA003]
An efficient asymmetric acyl-Mannich reaction of isoquinolines with alpha-(diazomethyl)phosphonate and diazoacetate has been developed using chiral spiro phosphoric acids as catalysts. This reaction allowed the construction of a series of chiral 1,2-dihydroisoquinolines bearing a tertiary stereocenter at the C1 position with up to 98% yield and 99% ee.
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