期刊
DALTON TRANSACTIONS
卷 49, 期 36, 页码 12643-12652出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0dt01591a
关键词
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资金
- Brazilian Research Agency: FAPEMIG
- Brazilian Research Agency: FAPESP
- Brazilian Research Agency: CNPq
- Brazilian Research Agency: CAPES
- CoordenacAo de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]
- CAPES (the PNPD program)
- PROPP/UFOP
- Universidade Federal de Ouro Preto (UFOP)
- Laboratorio Multiusuario de CaracterizacAo de Moleculas/UFOP
- FAPEMIG [APQ-01674-18]
- CNPq [403588/2016-2, 308370/2017-1]
- CAPES
Ruthenium(II) diclofenac-based complexes of the general formula (Ru(dicl)(P-P)(bpy)]PF6 (did = diclofenac, bpy = 2,2'-bipyridine, and P-P = 1,4'-bis(diphenylphosphino)butane (dppb) (1), 1,2'-bis(diphenylphosphino)ethane (dppe) (2), 1,3'-bis(diphenylphosphino)propane (dppp) (3) and 1,1'-bis(diphenylphosphino) ferrocene (dppf) (4)1 are synthesized. The complexes (1-4) are characterized by elemental analyses, infrared, NMR, and UV-vis spectroscopy and (3) and (4) are characterized by single crystal X-ray diffraction. The DNA binding of complexes (1-4), studied by circular dichroism (CD) and Hoechst 33 258 staining assay, indicates their binding with the minor grooves. The complexes interact with BSA with binding constants (K-b) in the range of 2.5 x 10(3) -5.5 x 10(4) M-1. The complexes exhibit high cytotoxicity against the tumor cell lines A549, MDA-MB-231, and MCF-7 with IC50 values ranging from 0.56 to 15.28 mu M. The complexes are more selective for the hormone-dependent MCF-7 breast tumor cell line and complex (1) is the most potent one. The study demonstrates the anticancer activity of ruthenium(ii)/diclofenac-based complexes.
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