期刊
MICROPOROUS AND MESOPOROUS MATERIALS
卷 307, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.micromeso.2020.110486
关键词
Ferrous sulfate; Mesoporous silica nanoparticles; Poisoning; Tannic acid
类别
资金
- Vice Chancellor for Research, Birjand University of Medical Sciences (BUMS), Birjand, Iran
In the present study, four types of Mesopomus Silica Nanoparticles (MSNs) were synthesized by two different synthesis methods using Cetyltrimethylammonium bromide (CTAB) or tannic acid as templating agents. Two of the 4 types of synthesized MSNs were functionalized with an amine group whereas the other two remained nonfunctionalized. Structure and functional groups of the MSNs were determined by Fourier-transform infrared (FT-IR) spectrometry, elemental analysis (CHN) and Thermogravimetric analysis (TGA). In addition to the evaluation of morphological aspects using transmission electron microscopy (TEM), the hydrodynamic dimensions of the MSNs were also evaluated by dynamic light scattering (DLS). The MSNs were monodispersed and spherical in shape, with approximate size of 100-260 nm. The pore sizes of the nanoparticles ranged from 4 to 5.5 nm, and the surface areas were around 370-740 m(2)/g. In the initial phase, the in vitro adsorption capacity of the synthesized nanoparticles for ferrous sulfate was assessed. Subsequently, the most effective nanoparticle, tannic acid-templated MSNs with amine group (TA-MSN-NH2), with the maximum adsorption capacity (29.06 (mg/g)) was selected for further in vivo study. In vivo analysis showed that 1 g/kg of TA-MSN-NH2 could be utilized to promote the adsorption of iron in acute oral toxicity with 100 mg/kg of ferrous sulfate.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据