期刊
MYCOPATHOLOGIA
卷 185, 期 6, 页码 975-982出版社
SPRINGER
DOI: 10.1007/s11046-020-00485-2
关键词
Meyerozyma guilliermondiicomplex; Candidemia; Cancer; Risk factor; Mortality
类别
资金
- Laboratory Medicine Innovation Unit, Chinese Academy of Medical Sciences [2019RU017]
- National Key Specialist Construction Project for Clinical Laboratory Medicine
AlthoughMeyerozyma guilliermondiicomplex is an uncommon cause of invasive candidiasis worldwide, reported cases, mainly regarding bloodstream infections, increased over years, and patients with cancer who have undergone recent surgery are most commonly affected. However, the clinical characteristics and outcomes of candidemia caused byM. guilliermondiicomplex remain poorly understood. A retrospective case-control study was conducted to evaluate the clinical characteristics and mortality of candidemia caused byM. guilliermondiicomplex in cancer patients undergoing surgery. Demographic and clinical data were collected from the hospital medical records system with a standardized data collection form and were analyzed with SPSS 20.0. Sixty-six cancer patients who have undergone recent surgery and were diagnosed with candidemia caused byM. guilliermondiicomplex were included in the study. Regarding the clinical manifestations, most patients' body temperatures ranged from 38 to 40 degrees C, with a median fever duration of 4 (IQR: 3-6) days. Multivariate analysis indicated that the presence of central venous catheter (OR: 6.68; 95% CI 2.80-15.94) and gastric tube (OR: 3.55; 95% CI 1.22-10.34) were independent risk factors forM. guilliermondiicomplex fungemia. The 30-day crude mortality of candidemia caused byM. guilliermondiicomplex was 12.1%, twice that of the control group. Moreover, increased WBC count, age >= 60 years, septic shock, and ICU admission were identified as predictors of mortality through univariate analysis. These findings will provide a foundation for the clinical management of candidemia caused byM. guilliermondiicomplex in post-surgical cancer patients.
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