FDA Label for Over-the-Counter Naloxone

To the Editor: Cohen et al. (May 28 issue)(1) describe the interest of the Food and Drug Administration in increasing the availability of naloxone for community use. However, we are confused about the statistics reported in Table 3 of the article. If 4.2%, 1.8%, and 9.7% of the participants had incorrect comprehension of steps 1, 2, and 3, respectively, the worst case (assuming that none of the participants had incorrect comprehension of more than one step) would be a composite percentage of 15.7%. However, the authors report a value of 18.9%. Can they explain this discrepancy? The authors reply: The . . .