期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 323, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2020.128705
关键词
Pillararenes; Host-guest chemistry; Nanochannnels; Biomimetic
资金
- National Key Research and Development Program of China [2018YFD0200102]
- National Natural Science Foundation of China [21772055, 21572076]
- Nature Science Foundation of Hubei Province [2018CFB534]
- 111 Project [B17019]
- Open Project of Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine [WDCM2019003]
N-acetylglucosamine analogues exist in nature as an important saccharide in human body and can regulate a variety of life activities captured through biological nanochannels. Herein we describe a biomimetic strategy via supramolecular host-guest chemistry for constructing artificial nanochannels to detect N-acetylglucosamine analogues. The functional nanochannels exhibited a high selectivity and good reversibility towards N-acetylglucosamine. Further studies indicate that the detecting behaviors was probably due to the multiple hydrogen bonding interactions and an appropriately fitting the functional and geometric requirements between the tryptophan-decorated pillararenes and N-acetylglucosamine, leading to the change of the surface charge and wettability within the nanochannels. These studies can give interesting insight for the research of biological processes caused by N-acetylglucosamine-sensitive ion channels, and also help to develop the platform for detecting N-acetylglucosamine in vitro.
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