期刊
ENVIRONMENTAL POLLUTION
卷 266, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2020.115204
关键词
Di-2-ethylhexyl phthalate (DEHP); 8-Oxo-2 '-deoxyguanosine (8-OHdG); Malondialdehyde (MDA); Phthalate -tainted foodstuff; Children
资金
- Kaohsiung Medical University Hospital [KMUH107-7R77]
- Kaohsiung Medical University Research Center Grant [KMU-TC108A01]
- Ministry of Science and Technology [MOST 106-2632-B-037-001-, MOST 106-2314-B037-030-MY3, MOST109-2314-B-037-066]
- Taiwan's National Health Research Institutes [NHRI-EX106-10209PI]
- Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan
A major health scandal involving DEHP-tainted (di-2-ethylhexyl phthalate) foodstuffs occurred in Taiwan in 2011. We investigated temporal relationships between urinary DEHP metabolites and biomarkers of oxidative stress in two cohorts of potentially affected children during that food scandal. One cohort was collected from Kaohsiung Medical University Hospital in southern Taiwan between May and June of 2011 (the KMUH cohort). This cohort was followed up at 2, 6, and 44 months. The other cohort was collected from a nationwide health survey conducted by Taiwan's National Health Research Institutes (the NHRI cohort) for potentially affected people between August 2012 and January 2013. Both cohorts only included children 10 years old and younger who had provided enough urine for analysis of urinary DEHP oxidative metabolites and two markers of oxidative stress: 8-oxo-2'-deoxyguanosine (8-OHdG) and malondialdehyde (MDA). The KMUH cohort had a simultaneous and significant decrease in urinary DEHP metabolites, 8-OHdG, and MDA, with the lowest concentrations found at the 6-month follow up and maintained until the 44-month follow up, consistent with those from NHRI cohort at similar to 15-18 months post-scandal (p > 0.05). There were decreases in both DEHP metabolites and oxidative stress markers across the populations, but no association was observed between DEHP metabolites and oxidative stress markers in individuals in the two cohorts. Continued follow-up is needed to determine long-term health consequences in these children. (C) 2020 Published by Elsevier Ltd.
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