期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 322, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2020.128564
关键词
Hydrogen polysulfides; Two-photon; Cell imaging; Fluorescent probe
资金
- National Research Foundation of Korea (NRF) - Korean government (MSIP) [2012R1A3A2048814, 2019R1A2B5B03100278]
- National Research Foundation of Korea [2019R1A2B5B03100278] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Hydrogen polysulfide (H2Sn) is an emerging topic of research because it plays a critical role in the pathological and physiological activities of an organism. Therefore, visual monitoring of H2Sn activity in living cells is critical. In our work, a two-photon fluorescent probe NI-H2Sn based on a naphthalimide skeleton was developed as a molecular tool for detecting hydrogen polysulfides in solution and live HeLa cells. NI-H2Sn showed rapid response and high sensitivity. Notably, hydrogen polysulfides in hippocampal tissue of mice could also be tracked using the probe under a two-photon fluorescence microscope. Therefore, this probe NI-H2Sn is expected to serve as a pragmatic tool for studying the physiological roles of hydrogen polysulfides in living cells and in vivo.
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