期刊
IN VIVO
卷 34, 期 5, 页码 2259-2268出版社
INT INST ANTICANCER RESEARCH
DOI: 10.21873/invivo.12036
关键词
TRPV1; obesity; renal ischemia/reperfusion; calcitonin gene-related peptide; inflammation
资金
- National Institutes of Health [HL-57853, HL-73287, DK67620]
Background/Aim: Transient receptor potential vanilloid type 1 (TRPV1) has anti-inflammatory properties. The present study aimed to investigate the role of TRPV1 in renal inflammatory responses and tissue injury following renal ischemia-reperfitsion (I/R) in diet-induced obese mice. Materials and Methods: TRPV1 knockout and wild type mice were fed a normal or western diet (WD) for 23 weeks and were then subjected to renal I/R injury. Results: TRPV1 knockout mice showed enhanced WD-induced renal macrophage infiltration and collagen deposition. Knocking out TRPV1 exacerbated renal I/R-induced increase of malondialdehyde, interleukin-6, monocyte chemoattractant protein-1, and NF-kappa B in obese mice. Similar results were observed in the expression of phosphorylated Smad1 and Smad2/3. Blockade of calcitonin gene-related peptide (CGRP) receptors with CGRP8-37 worsened the I/R-induced renal inflammation and injury. Conclusion: Our data indicate that preserving TRPV1 expression and function may prevent renal I/R injury in obesity likely through alleviating inflammatory responses.
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