期刊
CURRENT BIOLOGY
卷 25, 期 19, 页码 2466-2478出版社
CELL PRESS
DOI: 10.1016/j.cub.2015.08.028
关键词
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资金
- Agence Nationale de la Recherche (ANR)(Investmentsfit the future) [ANR-10-INSB-04]
- NeRF (Neuropole de recherche francilien)
- ARC (Association pour la Recherche sur le Cancer)
- FRM (Fondation pour la Recherche Medicale)
- Ile de France region DIM Cerveau et Pensee
- CNRS (Centre National de la Recherche Scientifique) Investigator
- Ecole des Neurosciences de Paris Ile-de-France (ENP)
- ANR [ANR-2011-BSV4-023-01]
- FRM (Equipe) [FRM DEQ20130326521]
- Ville de Paris [2006 ASES 102]
- Federation pour la Recherche sur le Cerveau (FRC)
- Fondation JED Belgique
- INSERM
- Association Francaise contre les Myopathies (AFM)
- Maine de Paris Medical Research and Health Program
- ENP
- Fondation Medicale Reine Elisabeth (FMRE)
In the neocortex, higher-order areas are essential to integrate sensory-motor information and have expanded in size during evolution. How higher-order areas are specified, however, remains largely unknown. Here, we show that the migration and distribution of early-born neurons, the Cajal-Retzius cells (CRs), controls the size of higher-order areas in the mouse somatosensory, auditory; and visual cortex. Using live imaging, genetics, and in silica modeling, we show that subtype-specific differences in the onset, speed, and directionality of CR migration determine their differential invasion of the developing cortical surface. CR migration speed is cell autonomously modulated by vesicle-associated membrane protein 3 (VAMP3), a classically non-neuronal mediator of endosomal recycling. Increasing CR migration speed alters their distribution in the developing cerebral cortex and leads to an expansion of postnatal higher-order areas and congruent rewiring of thalamo-cortical input. Our findings thus identify novel roles for neuronal migration and VAMP3-dependent vesicular trafficking in cortical wiring.
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