期刊
SCIENCE
卷 370, 期 6514, 页码 310-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aba2894
关键词
-
资金
- People Programme (Marie Sklodowska-Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under REA through the PRESTIGE programme [PCOFUND-GA-2013-609102]
- Marie Curie AMP
- PRESTIGE Fellowship [609102]
- London Law Trust Medal Fellowship [MGS9403]
- Austrian Research Promotion Agency (FFG) [875764]
- National Center of Competence in Research (NCCR) Molecular Systems Engineering
- Institut Pierre-Gilles de Gennes-IPGG [ANR-10-EQPX-34, ANR-10-IDEX-0001-02 PSL, ANR-10-LABX-31]
- Institut National du Cancer (INCa grant 2018-PL Bio-02)
- INCa (grant 2019-PL BIO-07)
- National Institute of General Medical Sciences of the National Institutes of Health [R01GM126054]
- National Institutes of Health [R35GM133522-01, R33CA235254-02]
- Instituto de Salud Carlos III (ISCIII) [PI17/01395, PI20/00306]
- I3 SNS program
- National Institute of General Medical Sciences [K99GM123221]
- Marie Sklodowska-Curie Individual Fellowship [DCBIO 751735]
- EMBO Long-Term Fellowship [ALTF 1298-2016]
- Metchnikov Fellowship from the Franco-Russian Scientific Cooperation Program
- Russian Science Foundation [16-15-10288]
- INSERM Plan Cancer Single Cell [19CS007-00]
- Russian Science Foundation [19-15-13020, 16-15-10288] Funding Source: Russian Science Foundation
The microscopic environment inside a metazoan organism is highly crowded. Whether individual cells can tailor their behavior to the limited space remains unclear. In this study, we found that cells measure the degree of spatial confinement by using their largest and stiffest organelle, the nucleus. Cell confinement below a resting nucleus size deforms the nucleus, which expands and stretches its envelope. This activates signaling to the actomyosin cortex via nuclear envelope stretch-sensitive proteins, up-regulating cell contractility. We established that the tailored contractile response constitutes a nuclear ruler-based signaling pathway involved in migratory cell behaviors. Cells rely on the nuclear ruler to modulate the motive force that enables their passage through restrictive pores in complex three-dimensional environments, a process relevant to cancer cell invasion, immune responses, and embryonic development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据