期刊
SCIENCE
卷 370, 期 6514, 页码 309-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aay8085
关键词
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资金
- Fundacio Marato de TV3 [31/U/2016]
- Australian Research Council Discovery Early Career Research Award [DE130100470]
- Early Postdoc Mobility fellowship from the Swiss National Science Foundation [P2ZHP3_184024]
- National Health and Medical Research Council (NHMRC) Senior Research Fellowship [APP1107914]
- CNIC IPP fellowship (COFUND 2014)
- Instituto de Salud Carlos III [FIS PI19/01410]
- Human Frontier Science Program (HFSP) [RGP0020/2015]
- Ministerio de Ciencia e Innovacion (MICINN) [RTI2018-098593-B-I00]
- CERCA Programme/Generalitat de Catalunya
- NHMRC of Australia [APP1037320, 569452]
- Australian Research Council Centre of Excellence in Convergent Bio-Nanoscience and Technology [CE140100036]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) of Brazil
- MICINN [SAF201451876-R, SAF2017-83130-R, MINSEV151207-2016, BIO2015-67580-P, SEV-2015-0505]
- Worldwide Cancer Research Foundation [15-0404]
- Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
- Carlos III Institute of Health-Fondo de Investigacion Sanitaria (PRB2, ProteoRed) [IPT13/0001-ISCIII-SGEFI/FEDER]
- MICINN
- Pro-CNIC Foundation
- Australian Research Council [DE130100470] Funding Source: Australian Research Council
- Swiss National Science Foundation (SNF) [P2ZHP3_184024] Funding Source: Swiss National Science Foundation (SNF)
Lipid droplets (LDs) are the major lipid storage organelles of eukaryotic cells and a source of nutrients for intracellular pathogens. We demonstrate that mammalian LDs are endowed with a protein-mediated antimicrobial capacity, which is up-regulated by danger signals. In response to lipopolysaccharide (LPS), multiple host defense proteins, including interferon-inducible guanosine triphosphatases and the antimicrobial cathelicidin, assemble into complex clusters on LDs. LPS additionally promotes the physical and functional uncoupling of LDs from mitochondria, reducing fatty acid metabolism while increasing LD- bacterial contacts. Thus, LDs actively participate in mammalian innate immunity at two levels: They are both cell-autonomous organelles that organize and use immune proteins to kill intracellular pathogens as well as central players in the local and systemic metabolic adaptation to infection.
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