期刊
CELL CALCIUM
卷 91, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2020.102278
关键词
TRP; Channel; Calcium; Mustard; Sensory; Pain
类别
资金
- National Institutes of Health [R01GM126581]
- FONDECYT grant [1191868]
- Millennium Nucleus of Ion Channels Associated Diseases (MiNICAD), Iniciativa Cientifica Milenio, Ministry of Economy, Development and Tourism, Chile
Novel structures of the human TRPA1 channel were determined in the presence of the agonist iodoacetamide and the antagonist A-967079, to reveal the open and closed states of the channel, respectively. The structures further revealed the location of Ca2+ modulatory site that is likely conserved among several TRP subgroups.
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