期刊
CHEMICAL SCIENCE
卷 11, 期 38, 页码 10414-10420出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0sc04091f
关键词
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资金
- NSFC [21871090]
- Ministry of Education (PCSIRT)
- Fundamental Research Funds for the Central Universities
An unprecedented gamma-carboxylation of alpha-CF3 alkenes with CO2 is reported. This approach constitutes a rare example of using electrochemical methods to achieve regioselectivity complementary to conventional metal catalysis. Accordingly, using platinum plate as both a working cathode and a nonsacrificial anode in a user-friendly undivided cell under constant current conditions, the gamma-carboxylation provides efficient access to vinylacetic acids bearing agem-difluoroalkene moiety from a broad range of substrates. The synthetic utility is further demonstrated by gram-scale synthesis and elaboration to several value-added products. Cyclic voltammetry and density functional theory calculations were performed to provide mechanistic insights into the reaction.
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