期刊
IMPLANT DENTISTRY
卷 26, 期 4, 页码 607-612出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/ID.0000000000000618
关键词
secretome; cytokine; paracrine; vasculization
资金
- Ministry of Health, Labour and Welfare of Japan [23592883]
- Grants-in-Aid for Scientific Research [16H05540, 23592883, 15K11213] Funding Source: KAKEN
Objective: This clinical study was undertaken to evaluate the safety of use of the secretome of bone marrow-derived mesenchymal stem cells (MSC-CM) for maxillary sinus floor elevation (SFE). Materials and Methods: MSC-CM was prepared from conditioned medium from human bone marrow-derived MSCs. Six partially edentulous patients were enrolled in the study. MSC-CM was mixed with porous beta-tricalcium phosphate (beta-TCP) and implanted in 4 patients (experimental group), whereas only beta-TCP was implanted in the other 2 patients (control group). Six months after SFE, bone biopsies and histological assessments were performed. Results: Bone formation was clinically confirmed in all cases. Although Hounsfield units in computed tomography images were not significantly different between the groups, histological analysis revealed a significant difference in newly formed bone area between the groups. In particular, bone volume in the center of the augmented area was significantly greater in the MSC-CM group. Newly formed bone consisted of lamellar bone in the MSC-CM group but woven bone in the beta-TCP group. Conclusion: The secretome of bone marrow-derived mesenchymal stem cells (MSC-CM) was used safely and has great osteogenic potential for regenerative medicine of bone.
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