期刊
IMMUNOTHERAPY
卷 9, 期 2, 页码 173-181出版社
FUTURE MEDICINE LTD
DOI: 10.2217/imt-2016-0116
关键词
cancer antigens; cancer vaccines; dendritic cells (DCs); gene transfer; leukemia next-generation vaccines
类别
Up to today treatment of leukemia patients remains challenging and different therapies have been developed, among them the generation of dendritic cell (DC) vaccines. DCs, highly specific for immunogenic cancer antigens, are generated either ex vivo or in vivo and boost the immune response against leukemic cells. Nevertheless, response rates are still heterogeneous and DC vaccines need improvement. New methods for generating DC vaccines have been summed up under the term `nextgeneration DC vaccines'. They range from the analysis of human leukocyte antigenligandomes to immunogenic cell death inducers, from the production of viral vectors to mRNA transfection and finally from delivering peptides to DCs in vivo through either antibodies or cell-penetrating peptides. This review gives an overview of the latest developments in this still evolving field.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据