期刊
MATERIALS HORIZONS
卷 7, 期 10, 页码 2696-2701出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0mh00931h
关键词
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资金
- National Science Foundation of China [21788102, 51620105009, 21877040, 21602063, U1801252]
- Science and Technology Planning Project of Guangzhou [201804020060, 201607020015, 201704030069]
- Pearl River S&T Nova Program of Guangzhou [201806010152]
- Natural Science Foundation of Guangdong Province [2020B1515020010, 2016A030312002]
- Fundamental Research Funds for the Central Universities [2018JQ01]
- Innovation and Technology Commission of Hong Kong [ITC-CNERC14SC01]
Chemotherapeutics with systemic administration usually suffer from low treatment efficacy and off-target toxicity. On the contrary, photoactivatable cancer theranostics can achieve image-guided precise control of therapeutic dose and location. However, the conventional photoactivatable chemotherapeutics usually require decoration of the chemotherapeutics with additional photo-responsive groups through tedious synthetic procedures, which can lead to undesirable toxic byproducts and seriously restrict their applications. Herein, we propose a new strategy for photoactivatable cancer theranostics based on a photooxidative dehydrogenation reaction, which is only associated with water as the byproduct. To demonstrate the power of this strategy, we utilized the natural dihydrobenzo[c]phenanthridine alkaloids of DHCHE and DHSAN as photoactivatable theranostics to achieve the selective imaging and killing of cancer cells byin situtransformation into nucleus-targeted CHE and SAN under light irradiation. Notably, CHE features aggregation-induced emission (AIE) characteristics, which can be used for the precise control of the photoactivatable therapeutic dose. This photoactivatable strategy based on a photooxidative dehydrogenation reaction is thus promising for precise cancer treatment in the clinic.
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