期刊
NEUROPSYCHOPHARMACOLOGY REPORTS
卷 40, 期 4, 页码 371-375出版社
WILEY
DOI: 10.1002/npr2.12146
关键词
fear conditioning; gratings; magnocellular; neocortex; visual cortex
资金
- Japan Society for the Promotion of Science [JP19590060]
- Ministry of Education, Culture, Sports, Science and Technology [JP20019016]
- Japan Science and Technology Agency
Aim Fear conditioning tests are intended to elucidate a subject's ability to associate a conditioned stimulus with an aversive, unconditioned stimulus, such as footshock. Among these tests, a paradigm related to precise cortical functions would be increasingly important in drug screening for disorders such as schizophrenia and dementia. Therefore, we established a new fear conditioning paradigm using a visual cue in mice. In addition, the validity of the test was evaluated using a genetically engineered mouse, heterozygous deficient inMdga1(Mdga1+/-), which is related to schizophrenia. Results Mice were given footshocks associated with a visual cue of moving gratings at training in 25-minute sessions. The mice showed the conditioned response of freezing behavior to the visual stimulus at testing 24 hours after the footshocks. In the test for validation, theMdga1+/- deficient mice showed significantly less freezing than wild-type mice. Conclusion The visually cued fear conditioning paradigm with moving gratings has been established, which is experimentally useful to evaluate animal cortical functions. The validity of the test was confirmed forMdga1-deficient mice with possible deficiency in cortical functions.
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