期刊
IMMUNOLOGY LETTERS
卷 188, 期 -, 页码 108-115出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2017.07.003
关键词
Myeloid-derived suppressor cells; MDSCs; B cells
类别
资金
- German Research Foundation (Deutsche Forschungsgemeinschaft, Emmy Noether Programme) [HA 5274/3-1, CRC/SFB685]
- CNPq (National Council for Scientific and Technological Development-Brazil)
- Ministry of Science, Research and Arts of Baden Wurttemberg [Az.: SI-BW 01222-91]
- Deutsche Forschungsgemeinschaft DFG (German Research Foundation) [Az.:INST 2388/33-1]
Myeloid-derived suppressor cells (MDSCs) are key regulators of adaptive immunity by suppressing T-cell functions. However, their potential action on or interaction with B cells remained poorly understood. Here we demonstrate that human polymorphonuclear MDSCs differentially modulate B-cell function by suppressing B cell proliferation and antibody production. We further demonstrate that this MDSC-mediated effect is cell contact dependent and involves established mediators such as arginase-1, nitric oxide (NO), reactive oxygen species (ROS) as well as B-cell death. Collectively, our studies provide novel evidence that human MDSCs modulate B cells, which could have future implications for immunotherapy approaches.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据