期刊
IMMUNOLOGY
卷 153, 期 4, 页码 423-434出版社
WILEY
DOI: 10.1111/imm.12877
关键词
inflammation; malaria; tolerance
类别
资金
- DELTAS Africa grant [DEL-15-007]
- Royal Society of Tropical Medicine and Hygiene Small Grant [GR000775]
- World Bank African Centres of Excellence grant [ACE02-WACCBIP: TWA]
- African Academy of Sciences (AAS)'s Alliance for Accelerating Excellence in Science in Africa (AESA)
- New Partnership for Africa's Development Planning and Coordinating Agency (NEPAD Agency)
- Wellcome Trust [107755/Z/15/Z: TWA]
- UK government
Immunity to malaria could be categorized broadly as antiparasite or antidisease immunity. While most vaccine research efforts have focused on antiparasite immunity, the evidence from endemic populations suggest that antidisease immunity is an important component of natural immunity to malaria. The processes that mediate antidisease immunity have, however, attracted little to no attention, and most interests have been directed towards the antibody responses. This review evaluates the evidence for antidisease immunity in endemic areas and discusses the possible mechanisms responsible for it. Given the key role that inflammation plays in the pathogenesis of malaria, regulation of the inflammatory response appears to be a major mechanism for antidisease immunity in naturally exposed individuals.
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