期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 16, 期 15, 页码 2761-2774出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.49665
关键词
PI4; 5P(2); membrane trafficking; PIPK; endosome; lysosome; autophagy
资金
- American Cancer Society [RSG-17-064-01-TBE]
- key disciplines group construction project of Pudong Health Bureau of Shanghai [PWZxq2017-04]
Phosphoinositides are membrane lipids generated by phosphorylation on the inositol head group of phosphatidylinositol. By specifically distributed to distinct subcellular membrane locations, different phosphoinositide species play diverse roles in modulating membrane trafficking. Among the seven known phosphoinositide species, phosphatidylinositol 4,5-bisphosphate (PI4,5P(2)) is the one species most abundant at the plasma membrane. Thus, the PI4,5P(2) function in membrane trafficking is first identified in controlling plasma membrane dynamic-related events including endocytosis and exocytosis. However, recent studies indicate that PI4,5P(2) is also critical in many other membrane trafficking events such as endosomal trafficking, hydrolases sorting to lysosomes, autophagy initiation, and autophagic lysosome reformation. These findings suggest that the role of PI4,5P(2) in membrane trafficking is far beyond just plasma membrane. This review will provide a concise synopsis of how PI4,5P(2) functions in multiple membrane trafficking events. PI4,5P(2), the enzymes responsible for PI4,5P(2) production at specific subcellular locations, and distinct PI4,5P(2) effector proteins compose a regulation network to control the specific membrane trafficking events.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据