期刊
IMMUNOLOGICAL REVIEWS
卷 275, 期 1, 页码 285-295出版社
WILEY-BLACKWELL
DOI: 10.1111/imr.12482
关键词
AIDS; antibodies; cytotoxicity; Fc receptors; immunotherapies; inflammation
类别
资金
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [P01AI100148]
- Bill & Melinda Gates Foundation [OPP1124068]
- amfAR, the American Foundation for AIDS Research [108977-57-RKVA]
- Bill and Melinda Gates Foundation [OPP1124068] Funding Source: Bill and Melinda Gates Foundation
The antiviral activity of antibodies reflects the bifunctional properties of these molecules. While the Fab domains mediate highly specific antigenic recognition to block virus entry, the Fc domain interacts with diverse types of Fc receptors (FcRs) expressed on the surface of effector leukocytes to induce the activation of distinct immunomodulatory pathways. Fc-FcR interactions are tightly regulated to control IgG-mediated inflammation and immunity and are largely determined by the structural heterogeneity of the IgG Fc domain, stemming from differences in the primary amino acid sequence of the various subclasses, as well as the structure and composition of the Fc-associated N-linked glycan. Engagement of specific FcR types on effector leukocytes has diverse consequences that affect several aspects of innate and adaptive immunity. In this review, we provide an overview of the complexity of FcR-mediated pathways, discussing their role in the in vivo protective activity of anti-HIV-1 antibodies. We focus on recent studies on broadly neutralizing anti-HIV-1 antibodies that revealed that Fc-FcR interactions are required to achieve full therapeutic activity through clearance of IgG-opsonized virions and elimination of HIV-infected cells. Manipulation of Fc-FcR interactions to specifically activate distinct FcR-mediated pathways has the potential to affect downstream effector responses, influencing thereby the in vivo protective activity of anti-HIV-1 antibodies; a strategy that has already been successfully applied to other IgG-based therapeutics, substantially improving their clinical efficacy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据