期刊
JOURNAL OF FUNCTIONAL FOODS
卷 74, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2020.104198
关键词
Trehalose; Photoaging; Oxidative stress; HaCaT cells; UVB
资金
- Natural Science Foundation of Guangdong Province [2020A1515011075]
- Yangfan Scarce Top Talent Project of Guangdong Province [201433009]
- 2020 Shenzhen International Scientific and technological cooperation RD project
- Development Project about Marine Economy Demonstration of Zhanjiang City [2017C8B1]
- Fund of Southern Marine Science and Engineering Guangdong Laboratory [ZJW-2019-07]
Ultraviolet radiation B cause photoaging of the skin by enhancing the high expression of matrix metalloproteinases (MMPs) to degrade collagen and inhibit the synthesis of procollagen. Trehalose (TRE), a widely occurring natural disaccharide, has been shown to play a cytoprotective role in many pathological processes. However, few studies have evaluated whether it has anti-photoaging potential. In this study, we investigated the anti-photoaging and mechanism of action of TRE using Human immortalized keratinocytes (HaCaT) cells. The results indicated that TRE pretreatment effectively scavenges reactive oxygen species (ROS) accumulation induced by UVB and increases the content of certain endogenous antioxidant factors in HaCaT cells. TRE suppressed UVB-induced MMP expression by blocking mitogen-activated protein kinases (MAPKs), activator protein 1 (AP-1) and NF-kappa B signaling. TRE treatment increased procollagen I synthesis via activating transforming growth factor-beta (TGF-beta)/Smad pathway and demonstrated that TRE may be a potential natural disaccharide for photoaging therapy in the future.
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