期刊
IMMUNOLOGICAL REVIEWS
卷 276, 期 1, 页码 178-191出版社
WILEY-BLACKWELL
DOI: 10.1111/imr.12526
关键词
cancer/tumor immunology; hypersialylation; immune evasion; immune regulation; inhibitory receptor; sialic acid; Siglec
类别
资金
- NIH [AI064930, AI110495]
- Mizutani Foundation
Many Siglecs function as inhibitory receptors on innate and adaptive immune cells and may contribute to the attenuation of immune responses to tumors. Siglec 9 on neutrophils and Siglec 7 on NK cells are prominent examples of inhibitory Siglecs that can potentially dampen anti-tumor immunity. CD169 is a Siglec that may function as an adhesion molecule and a facilitator of the recognition and internalization of sialic acid decorated apoptotic bodies and exosomes derived from tumors. It can potentially contribute to both the attenuation as well as the facilitation of anti-tumor immunity. Siglecs have been best studied in the tumor context in animal models of cancer. Modulators of Siglec function are likely to be developed and investigated clinically in a cancer context over the next few years.
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