期刊
IMMUNOLOGICAL REVIEWS
卷 281, 期 1, 页码 57-61出版社
WILEY
DOI: 10.1111/imr.12614
关键词
inflammation; inflammation-associated cancer; interleukin-1; therapy
类别
资金
- Fondazione Cariplo [2015-0564]
- Ministero della Salute [RF-2011-02348358, RF-2013-02355470]
- Ministry of Education, University and Research [PRIN 2015YYKPNN]
- European Research Council (ERC) [669415]
- Italian Association for Cancer Research [AIRC IG-19014, AIRC 5x1000-9962]
Inflammation is an important component of the tumor microenvironment. IL-1 is an inflammatory cytokine which plays a key role in carcinogenesis and tumor progression. IL-1 is subject to regulation by components of the IL-1 and IL-1 receptor (ILR) families. Negative regulators include a decoy receptor (IL-1R2), receptor antagonists (IL-1Ra), IL-1R8, and anti-inflammatory IL-37. IL-1 acts at different levels in tumor initiation and progression, including driving chronic non-resolving inflammation, tumor angiogenesis, activation of the IL-17 pathway, induction of myeloid-derived suppressor cells (MDSC) and macrophage recruitment, invasion and metastasis. Based on initial clinical results, the translation potential of IL-1 targeting deserves extensive analysis.
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