4.4 Article

FXR Agonists as Therapeutic Agents for Non-alcoholic Fatty Liver Disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Activation of farnesoid X receptor (FXR) protects against fructose-induced liver steatosis via inflammatory inhibition and ADRP reduction

Xijun Liu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease

Weibin Wu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

The FXR agonist 6ECDCA reduces hepatic steatosis and oxidative stress induced by ethanol and low-protein diet in mice

F. A. R. Livero et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2014)

Article Gastroenterology & Hepatology

Hepatic steatosis exacerbated by endoplasmic reticulum stress-mediated downregulation of FXR in aging mice

Xuelian Xiong et al.

JOURNAL OF HEPATOLOGY (2014)

Article Multidisciplinary Sciences

Bile Acids Reduce Endocytosis of High-Density Lipoprotein (HDL) in HepG2 Cells

Clemens Roehrl et al.

PLOS ONE (2014)

Article Substance Abuse

Temporal Effects of Ethanol Consumption on Energy Homeostasis, Hepatic Steatosis, and Insulin Sensitivity in Mice

Rotonya M. Carr et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2013)

Article Endocrinology & Metabolism

Genetic Variation in NR1H4 Encoding the Bile Acid Receptor FXR Determines Fasting Glucose and Free Fatty Acid Levels in Humans

Martin Heni et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

Article Medicine, Research & Experimental

The TGR5 receptor mediates bile acid-induced itch and analgesia

Farzad Alemi et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Review Gastroenterology & Hepatology

Bile Acid-Mediated Control of Liver Triglycerides

Claudia Fuchs et al.

SEMINARS IN LIVER DISEASE (2013)

Review Biochemistry & Molecular Biology

Anti-inflammatory and metabolic actions of FXR: Insights into molecular mechanisms

Danielle A. A. Hollman et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2012)

Article Gastroenterology & Hepatology

Independent Association Between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease in the US Population

Maria Stepanova et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2012)

Article Gastroenterology & Hepatology

Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis

Naoki Tanaka et al.

HEPATOLOGY (2012)

Article Biochemistry & Molecular Biology

The farnesoid X receptor -1G>T polymorphism influences the lipid response to rosuvastatin

Miao Hu et al.

JOURNAL OF LIPID RESEARCH (2012)

Article Gastroenterology & Hepatology

Frequency and Outcomes of Liver Transplantation for Nonalcoholic Steatohepatitis in the United States

Michael R. Charlton et al.

GASTROENTEROLOGY (2011)

Article Biochemistry & Molecular Biology

Nutritional Regulation of Bile Acid Metabolism Is Associated with Improved Pathological Characteristics of the Metabolic Syndrome

Bjorn Liaset et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Gastroenterology & Hepatology

A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis

Vlad Ratziu et al.

JOURNAL OF HEPATOLOGY (2011)

Article Gastroenterology & Hepatology

The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance

Tim C. M. A. Schreuder et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2010)

Article Pharmacology & Pharmacy

Vitamin E and Cardiovascular Disease

Adonis Saremi et al.

AMERICAN JOURNAL OF THERAPEUTICS (2010)

Article Gastroenterology & Hepatology

Epidemiology of Non-Alcoholic Fatty Liver Disease

Stefano Bellentani et al.

DIGESTIVE DISEASES (2010)

Article Gastroenterology & Hepatology

Randomized Controlled Trial Testing the Effects of Weight Loss on Nonalcoholic Steatohepatitis

Kittichai Promrat et al.

HEPATOLOGY (2010)

Article Endocrinology & Metabolism

FXR Regulates Liver Repair after CCl4-Induced Toxic Injury

Zhipeng Meng et al.

MOLECULAR ENDOCRINOLOGY (2010)

Review Gastroenterology & Hepatology

The role of the gut microbiota in nonalcoholic fatty liver disease

Ahmed Abu-Shanab et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2010)

Article Medicine, General & Internal

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis.

Arun J. Sanyal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Gastroenterology & Hepatology

NAFLD as a Risk Factor for the Development of Diabetes and the Metabolic Syndrome: An Eleven-Year Follow-up Study

Leon A. Adams et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2009)

Article Cardiac & Cardiovascular Systems

Antiatherosclerotic effect of farnesoid X receptor

Andrea Mencarelli et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)

Article Gastroenterology & Hepatology

Long-Term Follow-Up of Patients With Nonalcoholic Fatty Liver

Nila Rafiq et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2009)

Article Gastroenterology & Hepatology

Orlistat for Overweight Subjects with Nonalcoholic Steatohepatitis: A Randomized, Prospective Trial

Stephen A. Harrison et al.

HEPATOLOGY (2009)

Article Medicine, General & Internal

Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers The Selenium and Vitamin E Cancer Prevention Trial ( SELECT)

Scott M. Lippman et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2009)

Review Biochemistry & Molecular Biology

What Is the Metabolic Role of Phosphoenolpyruvate Carboxykinase?

Jianqi Yang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Review Biochemistry & Molecular Biology

Bile acids: regulation of apoptosis by ursodeoxycholic acid

Joana D. Amaral et al.

JOURNAL OF LIPID RESEARCH (2009)

Article Endocrinology & Metabolism

Significance and Mechanism of CYP7a1 Gene Regulation during the Acute Phase of Liver Regeneration

Lisheng Zhang et al.

MOLECULAR ENDOCRINOLOGY (2009)

Review Physiology

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

Philippe Lefebvre et al.

PHYSIOLOGICAL REVIEWS (2009)

Article Gastroenterology & Hepatology

Inhibition of ADRP prevents diet-induced insulin resistance

Gladys M. Varela et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)

Review Hematology

Fatty liver - A novel component of the metabolic syndrome

Anna Kotronen et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008)

Article Gastroenterology & Hepatology

Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis

Guruprasad P. Aithal et al.

GASTROENTEROLOGY (2008)

Article Gastroenterology & Hepatology

Farnesoid X Receptor Antagonizes Nuclear Factor κB in Hepatic Inflammatory Response

Yan-Dong Wang et al.

HEPATOLOGY (2008)

Article Medicine, General & Internal

Comparison of strategies for sustaining weight loss - The weight loss maintenance randomized controlled trial

Laura P. Svetkey et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2008)

Article Medicine, Research & Experimental

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

Catherine Postic et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

Review Gastroenterology & Hepatology

Nuclear factor-κB and the hepatic inflammation-fibrosis-cancer axis

Ahmed M. Elsharkawy et al.

HEPATOLOGY (2007)

Article Endocrinology & Metabolism

Peroxisome proliferator-activated receptor α protects against obesity-induced hepatic inflammation

Rinke Stienstra et al.

ENDOCRINOLOGY (2007)

Article Oncology

Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice

Insook Kim et al.

CARCINOGENESIS (2007)

Article Medicine, General & Internal

A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis

Renata Belfort et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Gastroenterology & Hepatology

Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation

JK Reddy et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)

Article Medicine, Research & Experimental

Farnesoid X receptor is essential for normal glucose homeostasis

K Ma et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Physiology

Development of insulin resistance and hyperphagia in Zucker fatty rats

HA Durham et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2006)

Review Biochemistry & Molecular Biology

Bile salt biotransformations by human intestinal bacteria

JM Ridlon et al.

JOURNAL OF LIPID RESEARCH (2006)

Review Pathology

Mouse models in non-alcoholic fatty liver disease and steatohepatitis research

QM Anstee et al.

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2006)

Article Biochemistry & Molecular Biology

Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein

BHJ Chang et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Article Gastroenterology & Hepatology

Design and validation of a histological scoring system for nonalcoholic fatty liver disease

DE Kleiner et al.

HEPATOLOGY (2005)

Article Endocrinology & Metabolism

Regulation of carbohydrate metabolism by the farnesoid X receptor

KR Stayrook et al.

ENDOCRINOLOGY (2005)

Article Gastroenterology & Hepatology

MELD accurately predicts mortality in patients with alcoholic hepatitis

W Dunn et al.

HEPATOLOGY (2005)

Article Endocrinology & Metabolism

Glucose regulates the expression of the farnesoid X receptor in liver

D Duran-Sandoval et al.

DIABETES (2004)

Article Gastroenterology & Hepatology

Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome

G Marchesini et al.

HEPATOLOGY (2003)

Article Biochemistry & Molecular Biology

A G protein-coupled receptor responsive to bile acids

Y Kawamata et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

The farnesoid X-receptor is an essential regulator of cholesterol homeostasis

G Lambert et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation

YQ Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Medicine, Research & Experimental

Role of AMP-activated protein kinase in mechanism of metformin action

GC Zhou et al.

JOURNAL OF CLINICAL INVESTIGATION (2001)

Article Endocrinology & Metabolism

Nonalcoholic fatty liver disease - A feature of the metabolic syndrome

G Marchesini et al.

DIABETES (2001)

Article Biochemistry & Molecular Biology

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

B Goodwin et al.

MOLECULAR CELL (2000)

Review Physiology

Leptin

RS Ahima et al.

ANNUAL REVIEW OF PHYSIOLOGY (2000)