期刊
IMMUNITY
卷 46, 期 1, 页码 29-37出版社
CELL PRESS
DOI: 10.1016/j.immuni.2016.12.013
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资金
- Collaboration for AIDS Vaccine Discovery of the Bill and Melinda Gates Foundation
- International AIDS Vaccine Initiative (IAVI) [UKZNRSA1001]
- NIAID [1R01AI111918, R01AI067073]
- Harvard Center for AIDS Research
- Burroughs Wellcome Fund
- National Institute of General Medical Sciences [T32GM007753]
- NIH [AI1113217]
- Doris Duke Clinical Scientist Development Award
Elevated inflammation in the female genital tract is associated with increased HIV risk. Cervicovaginal bacteria modulate genital inflammation; however, their role in HIV susceptibility has not been elucidated. In a prospective cohort of young, healthy South African women, we found that individuals with diverse genital bacterial communities dominated by anaerobes other than Gardnerella were at over 4-fold higher risk of acquiring HIV and had increased numbers of activated mucosal CD4(+) T cells compared to those with Lactobacillus crispatus- dominant communities. We identified specific bacterial taxa linked with reduced (L. crispatus) or elevated (Prevotella, Sneathia, and other anaerobes) inflammation and HIV infection and found that high-risk bacteria increased numbers of activated genital CD4(+) T cells in a murine model. Our results suggest that highly prevalent genital bacteria increase HIV risk by inducing mucosal HIV target cells. These findings might be leveraged to reduce HIV acquisition in women living in sub-Saharan Africa.
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