期刊
IMMUNITY
卷 46, 期 2, 页码 176-182出版社
CELL PRESS
DOI: 10.1016/j.immuni.2017.02.005
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资金
- U.S. Military Research and Materiel Command
- U.S. Military HIV Research Program [W81XWH-11-2-0174]
- NIH [AI095985, AI096040, AI100663, AI124377]
- Ragon Institute of MGH, MIT, and Harvard
A recent unprecedented outbreak of Zika virus (ZIKV) in the Americas has been associated with microcephaly and other congenital malformations in infants as well as Guillain-Barre syndrome in adults. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Promising data from preclinical vaccine studies in mice and monkeys suggest that an effective vaccine will likely be possible, but important scientific challenges remain. Here we review the current state of ZIKV vaccine development. We discuss different vaccination strategies and we highlight challenges facing clinical evaluation of ZIKV vaccine candidates.
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