期刊
CHEMICAL SCIENCE
卷 11, 期 39, 页码 10786-10791出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0sc01445a
关键词
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资金
- European Research Council [681292]
- European Research Council (ERC) [681292] Funding Source: European Research Council (ERC)
Convergent paired electrosynthesis is an energy-efficient approach in organic synthesis; however, it is limited by the difficulty to match the innate redox properties of reaction partners. Here we use nickel catalysis to cross-couple the two intermediates generated at the two opposite electrodes of an electrochemical cell, achieving direct arylation of benzylic C-H bonds. This method yields a diverse set of diarylmethanes, which are important structural motifs in medicinal and materials chemistry. Preliminary mechanistic study suggests oxidation of a benzylic C-H bond, Ni-catalyzed C-C coupling, and reduction of a Ni intermediate as key elements of the catalytic cycle.
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