期刊
CHEMICAL COMMUNICATIONS
卷 56, 期 80, 页码 11941-11944出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc05264g
关键词
-
资金
- Research Grants Council of the Hong Kong Special Administrative Region, China [14304817]
- Direct Grant for Research of The Chinese University of Hong Kong [4053277]
A novel synthetic strategy for in situ cyclisation of peptides and conjugation with functional boron dipyrromethenes (BODIPYs) has been developed. Linear peptides with up to 16 amino acid residues can be cyclised effectively and the resulting conjugates can be isolated in higher than 20% yield. One of the conjugates having a cyclic RGD moiety has been studied both in vitro and in vivo. It exhibits high and selective affinity towards the alpha(v)beta(3)-positive cell lines and induces high photocytotoxicity. The conjugate can also selectively localise in and effectively inhibit the growth of alpha(v)beta(3)-overexpressed tumour in vivo.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据