期刊
CELL
卷 183, 期 3, 页码 594-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2020.09.008
关键词
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资金
- New York Stem Cell Foundation
- Searle Scholars Program
- Sloan Foundation
- Klingenstein-Simons Fellowship
- NIH [R00DK115879]
- Swiss National Science Foundation [P400PB-180894]
- Swiss National Science Foundation (SNF) [P400PB_180894] Funding Source: Swiss National Science Foundation (SNF)
Animals display wide-ranging evolutionary adaptations based on their ecological niche. Octopuses explore the seafloor with their flexible arms using a specialized taste by touch system to locally sense and respond to prey-derived chemicals and movement. How the peripherally distributed octopus nervous system mediates relatively autonomous arm behavior is unknown. Here, we report that octopus arms use a family of cephalopod-specific chemotactile receptors (CRs) to detect poorly soluble natural products, thereby defining a form of contact-dependent, aquatic chemosensation. CRs form discrete ion channel complexes that mediate the detection of diverse stimuli and transduction of specific ionic signals. Furthermore, distinct chemo- and mechanosensory cells exhibit specific receptor expression and electrical activities to support peripheral information coding and complex chemotactile behaviors. These findings demonstrate that the peripherally distributed octopus nervous system is a key site for signal processing and highlight how molecular and anatomical features synergistically evolve to suit an animal's environmental context.
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