期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 162, 期 -, 页码 116-126出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.06.150
关键词
Plukenetia volubilis L. seed; Polysaccharides structure; Immunostimulatory activity
资金
- Natural Science Foundation of Guangdong Province [2020A151501268]
- Key-Area Research and Development Program of Guangdong Province [2020B020226008]
- ScienceandTechnology Planning Project of Guangzhou City [201804010298]
In this study, a novel water-soluble polysaccharide (PVLP-1) was extracted and purified from Sacha inchi (Plukenetia volubilis L.) seeds and the structure, antioxidant and immunomodulatory activity of PVLP-1 were investigated. PVLP-1 (144 kDa) consisted of glucose (69.76%), mannose (14.86%), arabinose (10.53%), galactose (2.42%), ribose (1.23%), rhamnose (0.27%) and xylose (0.93%). PVLP-1 displayed characteristic polysaccharide bands in Fourier transform NMR spectra and infrared. The primary structure of PVLP-1 was a heteropolysaccharide with a backbone of (1 -> 6)-linked glucose, sidechains of (1 -> 4)-linked mannose, (1 -> 4)-linked glucose and (1 -> 3, 6)-linked mannose and a residue unit of -> 1)-linked arabinose as revealed the methylation analysis. PVLP-1 possessed good water-holding capacity (WHC), oil-holding capacity (OHC) and antioxidant capacities. Besides, PVLP-1 induced the proliferation of RAW264.7 cell and enhanced the expression of inflammatory cytokines IL-6, TNF-alpha(TNF-alpha) and IL-1 beta (IL-1 beta). The present study indicated that PVLP-1 possessed immune-enhancing bioactivities and could be functional food or adjuvant drug to improve biological immunity of immunodeficiency diseases and hypoimmunity. (c) 2020 Elsevier B.V. All rights reserved.
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