Fe doping induced enhancement in room temperature ferromagnetism and selective cytotoxicity of CeO2 nanoparticles

In the present study, structural, optical, magnetic properties as well as cytotoxicity of undoped and Fe doped Ceria (CeO2) nanoparticles synthesized by simple soft chemical method have been reported. SEM and XRD results have shown that the synthesized samples are comprised of ultrafine spherical nanoparticles having single phase cubic fluorite structure of CeO2. Raman spectroscopy results have depicted a red shift in F-2g mode with Fe doping which reveals enhancement in the oxygen vacancies. The optical band gap calculated from UV-visible absorption spectra has been found to vary unsystematically with Fe doping which is associated with the creation of impurity level and abundance in oxygen vacancies with Fe doping. The oxygen vacancies have introduced the room temperature ferromagnetism (RTFM) in undoped and Fe doped CeO2 nanoparticles. The saturation magnetization (M-s) value of pristine CeO2 nanoparticles has been found to be 0.00083 emu/g which is increased up to 0.0126 emu/g for 7% Fe doped nanoparticles. For cytotoxicity tests, the synthesized nanoparticles induced effects on Neuroblastoma cancer cells & HEK-293 healthy cells have been analyzed via CCK-8 analysis. It has been observed that the prepared undoped and Fe doped CeO2 nanoparticles have nontoxic nature towards healthy cells while they are extremely toxic towards cancerous cells. Furthermore, the anticancer activity is found to enhance with Fe doping. The selective toxicity and enhancement in anticancer activity with Fe doping has observed to be strongly correlated with reactive oxygen species (ROS) generation. (C) 2015 Elsevier B.V. All rights reserved.