期刊
IET NANOBIOTECHNOLOGY
卷 11, 期 7, 页码 883-888出版社
INST ENGINEERING TECHNOLOGY-IET
DOI: 10.1049/iet-nbt.2017.0025
关键词
iron compounds; nanoparticles; nanomedicine; biomedical materials; microorganisms; cellular biophysics; toxicology; drugs; scanning electron microscopy; X-ray diffraction; Fourier transform infrared spectra; antifungal effect; iron-oxide nanoparticles; Candida species; biodegradable effects; cytotoxic effects; reactive surface; biocompatible coatings; medical applications; IONP; fungal infections; Candidiasis; immunocompromised hosts; antifungal drugs; resistant organisms; antifungal properties; side effects; chemical drugs; scanning electron microscopy; X-ray diffraction; Fourier transform infrared spectroscopy; vibrating sample magnetometer; antifungal activity; disc diffusion; broth microdilution; minimal inhibitory concentration; minimum fungicidal concentration; Candida tropicalis; Candida Albicans; Candida glabrata; antifungal potential; Fe3O4
资金
- Kerman University of Medical Sciences [94/636]
Iron-oxide nanoparticles (IONPs) have been widely favoured due to their biodegradable, low cytotoxic effects and having reactive surface which can be altered with biocompatible coatings. Considering various medical applications of IONPs, the authors were encouraged to study whether IONPs could be effective against fungal infections caused by Candida species. In this study, IONPs were characterised by scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy and vibrating sample magnetometer. The goal of this study was to evaluate the antifungal activity of IONPs against different Candida spp. compared with fluconazole (FLC). IONPs were spherical with the size of 30-40 nm. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values of IONPs ranged from 62.5 to 500 mu g/ml and 500 to 1000 mu g/ml, respectively. The MIC and MFC of FLC were in range of 16-128 mu g/ml and 64-512 mu g/ml, respectively. The growth inhibition value indicated that Candida tropicalis, Candida albicans and Candida glabrata spp. were most susceptible to IONPs. The finding showed that the IONPs possessed antifungal potential against pathogenic Candida spp. and could inhibit the growth of all the tested Candida spp. Further studies, both in vitro and in vivo (including susceptibility, toxicity, Probability of kill (PK) and efficacy studies) are needed to determine whether IONPs are suitable for medicinal purposes.
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