期刊
MARINE DRUGS
卷 18, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/md18110553
关键词
Penicillium cyclopium; marine sediment-derived fungus; quinazoline alkaloid; polyketide derivatives; antibacterial activity
资金
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA22050401]
- National Natural Science Foundation of China [31700043]
- Aoshan Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology [2016ASKJ14]
- Research Vessel KEXUE of the National Major Science and Technology Infrastructure from the Chinese Academy of Sciences [KEXUE2018G28]
- Taishan Scholar Project from Shandong Province
- Qingdao National Laboratory for Marine Science and Technology [OF2019NO03]
Nine secondary metabolites (1-9), including two new polyketide derivatives 9-dehydroxysargassopenilline A (4) and 1,2-didehydropeaurantiogriseol E (5), along with seven known related secondary metabolites (1-3 and 6-9), were isolated and identified from the deep sea-derived fungus Penicillium cyclopium SD-413. Their structures were elucidated on the basis of 1D/2D NMR spectroscopic and mass spectrometric analysis and the absolute configurations were determined by the combination of NOESY correlations and time-dependent density functional (TDDFT) ECD calculations. Compounds 1-9 inhibited some pathogenic bacteria including Escherichia coli, E. ictaluri, Edwardsiella tarda, Micrococcus luteus, Vibrio anguillarum, and V. harveyi, with MIC (minimum inhibitory concentration) values ranging from 4 to 32 mu g/mL.
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