期刊
BIOMEDICINES
卷 8, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines8110462
关键词
ACE2; coronavirus; COVID-19; endothelium; epigenetics; HMVEC-L; HUVEC; lung; microRNA; miR-98-5p; non-coding RNA; SARS-CoV-2
资金
- NIH [R01-DK123259, R00-DK107895, R01-HL146691, R01-DK033823]
The two main co-factors needed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter human cells are angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). Here, we focused on the study of microRNAs that specifically target TMPRSS2. Through a bioinformatic approach, we identified miR-98-5p as a suitable candidate. Since we and others have shown that endothelial cells play a pivotal role in the pathogenesis of the coronavirus disease 2019 (COVID-19), we mechanistically validated miR-98-5p as a regulator of TMPRSS2 transcription in two different human endothelial cell types, derived from the lung and from the umbilical vein. Taken together, our findings indicate that TMPRSS2 represents a valid target in COVID-19 treatment, which may be achieved by specific non-coding-RNA approaches.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据