Cytotoxic compound triacremoniate from Marine Fungus Acremonium citrinum. MMF4

Two new compounds, triacremoniate (1) and dietziamide C (2) along with known compounds beta-Adenosine (3) and acrepymne A (4) were obtained from the mangrove-derived fungus Acremonium citrinum. MMF4. Their structures were unambiguously determined by extensive spectroscopic methods, including UV, IR, HRESIMS and NMR. Triacremoniate (1) can promote apoptosis of HeLa cells by increasing the PARP cleavage and the phosphorylation of JNK and p38.