期刊
MICROBIAL CELL
卷 7, 期 10, 页码 255-269出版社
SHARED SCIENCE PUBLISHERS OG
DOI: 10.15698/mic2020.10.731
关键词
autophagy; caloric restriction mimetics; dietary supplements; hormesis; phytochemicals
资金
- Primordia Institute of New Sciences and Medicine
- Taiwan's Ministry of Science and Technology [MOST 109-2311-B-182-001-MY2]
- Chang Gung University [NMRPD1K0031]
The nematode Caenorhabditis elegans is a useful model to study aging due to its short lifespan, ease of manipulation, and available genetic tools. Several molecules and extracts derived from plants and fungi extend the lifespan of C. elegans by modulating aging-related pathways that are conserved in more complex organisms. Modulation of aging pathways leads to activation of autophagy, mitochondrial biogenesis and expression of antioxidant and detoxifying enzymes in a manner similar to caloric restriction. Low and moderate concentrations of plant and fungal molecules usually extend lifespan, while high concentrations are detrimental, consistent with a lifespan-modulating mechanism involving hormesis. We review here molecules and extracts derived from plants and fungi that extend the lifespan of C. elegans, and explore the possibility that these natural substances may produce health benefits in humans.
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