期刊
THERANOSTICS
卷 10, 期 25, 页码 11719-11736出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.47682
关键词
biliverdin; silk fibroin; hydrogel; photothermal therapy; wound healing
资金
- National Natural Science Foundation of China [81903551, 81772316, 81803443]
- Zhejiang Province Natural Science Foundation [LQ19H300001, LY19H180001]
- Key Research and Development Program of Zhejiang Province [2018C03013]
- Zhejiang provincial program for the cultivation of high-level innovative health talents
- 151 talent project of Zhejiang province
- 551 talent projects of Wenzhou
- Wenzhou municipal science and technology bureau [Y20190177, ZY2019007, Y20180180, Y20180208]
Rationale: Photothermal therapy employs the photoabsorbers to generate heat under the near-infrared (NIR) irradiation for thermal tumor ablation. However, NIR irradiation might damage the adjacent tissue due to the leakage of the photoabsorbers and the residual materials after treatment might hinder the local healing process. A bifunctional hydrogel that holds both photothermal property and potent pro-healing ability provides a viable option to resolve this issue. Methods: In this study, we developed a bioinspired green hydrogel (BVSF) with the integration of bioproduct biliverdin into natural derived silk fibroin matrix for antiglioma photothermal therapy and wound healing. Results: The BVSF hydrogel possessed excellent and controllable photothermal activity under NIR irradiation and resulted in effective tumor ablation both in vitro and in vivo. Additionally, the BVSF hydrogel exerted anti-inflammatory effects both in vitro and in vivo, and stimulated angiogenesis and wound healing in a full-thickness defect rat model. Conclusion: Overall, this proof-of-concept study was aimed to determine the feasibility and reliability of using an all-natural green formulation for photothermal therapy and post-treatment care.
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