期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 45, 期 11, 页码 992-1003出版社
CELL PRESS
DOI: 10.1016/j.tibs.2020.08.003
关键词
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资金
- Fondo Europeo de Desarrollo Regional (FEDER) [BIO2016-76063-R, PID2019-105416RB-I00]
- Agencia Estatal de Investigacion (AEI) [BIO2016-76063-R, PID2019-105416RB-I00]
- AGAUR [2017SGR-229, 2017SGR-865 GRC, 2019 FI_B 00352]
- ISCIII (FEDER) [PIE15//00028, PI18/00650]
- EU COST Action [CA 17140]
- VI National R&D&I Plan 2008-2011
- Instituto de Salud Carlos III
- European Regional Development Fund
- ICREA ACADEMIA award
- Miguel Servet program from ISCIII (Fondo Social Europeo, FSE) [CP19/00028]
- Iniciativa Ingenio 2010
- Consolider Program
- CIBER Actions
Among inorganic materials, divalent cations modulate thousands of physiological processes that support life. Their roles in protein assembly and aggregation are less known, although they are progressively being brought to light. We review the structural roles of divalent cations here, as well as the novel protein materials that are under development, in which they are used as glue-like agents. More specifically, we discuss how mechanically stable nanoparticles, fibers, matrices, and hydrogels are generated through their coordination with histidine-rich proteins. We also describe how the rational use of divalent cations combined with simple protein engineering offers unexpected and very simple biochemical approaches to biomaterial design that might address unmet clinical needs in precision medicine.
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