期刊
ANALYTICA CHIMICA ACTA
卷 1136, 期 -, 页码 157-167出版社
ELSEVIER
DOI: 10.1016/j.aca.2020.09.049
关键词
Metal-organic frameworks; Anti-inflammatory drugs; Solid-phase extraction; Supported polymeric membrane
资金
- Facultad de Ciencias Quimicas and Research funding program PAICyT-UANL [CE858-19, CN1283-20]
- Spanish Agencia Estatal de Investigacion (AEI)
- European Funds for Regional Development (FEDER) (AEI/FEDER, UE) [CTQ2016-77155-R]
- CONACyT-Mexico
A solid-phase extraction methodology using a MIL-101(Fe)/PVDF membrane was proposed as a useful alternative for the simultaneous determination of naproxen, diclofenac, and ibuprofen, three anti-inflammatory drugs (NSAIDs), in wastewater samples by HPLC-CCD analysis. The MIL-101(Fe) was prepared by a rapid microwave-assisted method and supported in a polymeric PVDF membrane. The prepared material was characterized by X-ray diffraction (XRD), nitrogen adsorption-desorption, scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and Fourier-transform infrared spectroscopy (FT-IR). The factors that affect the extraction of the NSAIDs using the MIL-101(Fe)/PVDF membrane as the sample volume, the solution pH and the elution solvent were studied in detail. The selected conditions were 50 mL of sample solution at pH 3 and 5 mL of methanol: acetone (30:70, v v(-1)) acidified with formic acid at 2% as elution solvent. The analytical method was linear with determination coefficients (r(2) >= 0.998) in the calibration ranges from 2 to 100 ng mL(-1) for naproxen, 20-200 ng mL(-1) for diclofenac, and 100-300 ng mL(-1) for ibuprofen. The intra and inter-day precision (repeatability and reproducibility, respectively) of the method (RSD%, n = 5) were lower than 4.8% and 7.1%, respectively. The accuracy reported as recovery percentages ranged from 82 to 118%, and the limits of detection were between 1.8 and 32.3 ng mL(-1). Moreover, MIL-101(Fe)/PVDF membrane exhibited improved adsorption efficiency compared to that of its analog MIL-101(Cr)/PVDF and the pristine PVDF membranes, obtaining in an easy and rapid (60 min) way a low-cost and low-toxic adsorbent with excellent stability, reusability, mechanic resistance, and simple operation which shows excellent performance. (C) 2020 Elsevier B.V. All rights reserved.
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