期刊
ADVANCED SCIENCE
卷 7, 期 24, 页码 -出版社
WILEY
DOI: 10.1002/advs.202001191
关键词
angiogenesis; chemotherapy; photothermal therapy; prodrug; zirconium carbide
资金
- National Natural Science Foundation of China [61435010, 61575089, U1803128]
- Science and Technology Innovation Commission of Shenzhen [KQTD2015032416270385, JCYJ20150625103619275, JCYJ20180305124854790, KQJSCX20180321164801762]
- China Postdoctoral Science Foundation [2017M610540, 2018T110892, 2018M643364]
- Start-up Fund of Natural Science Foundation of Guangdong Province, China [2018A030310040, 2018A030310500]
- Natural Science Foundation of Shandong Province, China [ZR2016BB33]
- CRI project from the National Research Foundation of Korea [2018R1A3B1052702]
- Taishan Scholar Project of Shandong Province [tsqn201909054]
- National Research Foundation of Korea [4120200213669] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Conventional chemotherapy and photothermal therapy (PTT) face many major challenges, including systemic toxicity, low bioavailability, ineffective tissue penetration, chemotherapy/hyperthermia-induced inflammation, and tumor angiogenesis. A versatile nanomedicine offers an exciting opportunity to circumvent the abovementioned limitations for their successful translation into clinical practice. Here, a promising biophotonic nanoplatform is developed based on the zirconium carbide (ZrC) nanosheet as a deep PTT-photosensitizer and on-demand designed anticancer prodrug SN38-Nif, which is released and activated by photothermia and tumor-overexpressed esterase. In vitro and in vivo experimental evidence shows the potent anticancer effects of the integrated ZrC@prodrug biophotonic nanoplatform by specifically targeting malignant cells, chemotherapy/hyperthermia-induced tumor inflammation, and angiogenesis. In mouse models, the ZrC@prodrug system markedly inhibits tumor recurrence, metastasis, inflammation and angiogenesis. The findings unravel a promising biophotonic strategy for precision treatment of cancer.
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